H-Cube®
Next Generation Hydrogenation
FeaTureS
1. Touch screen panel
The H-Cube® represents the first in a new wave of continu-
Every operational step of the H-Cube® is
ous flow hydrogenation reactors. Utilizing water electrolysis to
conveniently controlled using a touch
generate hydrogen, a catalyst cartridge system (CatCart®), and
screen panel. Parameters such as
a continuous flow mechanism, H-Cube® makes hydrogenation
temperature, pressure, hydrogen pro-duction, and flow-rate can be adjusted
safer, more efficient, and easier to perform.
through the screen, providing simple and rapid reaction set-up, system
· A continuous flow of substrate is combined with hydrogen,
mo-nitoring, and reaction controll.
generated in-situ from the electrolysis of water
· The hydrogen/substrate mixture can be heated and pressu-
rized up to 100°C and 100 bar (1450 psi) respectively
· The mixture is then passed through a packed catalyst
2. Solvent/Substrate inlet
cartridge (CatCart®), where the reaction takes place
The solvent/substrate is introduced into the reactor at a steady flow via an
Within 2 minutes, product emerges for fast reduction and
external HPLC pump.
optimization. Reductions varying in scale from 10 mg-100 g can be performed on the same compact reactor.
H-Cube® is capable of hydrogenating a wide range of dif erent functional groups, for example:
· Nitro reductions· Alkene and alkyne saturation
3. Heating unit
· N- and O-debenzylations
The heating unit heats both the re-
· Nitrile reductions
action line and the catalyst cartridge
· Heterocycle saturation
(CatCart®) up to temperatures of 100°C.
· Imine reduction
The low volumes of substrate and
· Desulfurization
hydrogen mean that heating is quick
· Dehalogenation
and efficient, while easy to monitor and control.
Catalyst selection or varying the amount of hydrogen produced on the H-Cube® can be used to perform selective reductions.
advaNTageS
4. ThalesNano's CatCart®Thales´ CatCart® are sealed cartridges
Safer
containing heterogeneous catalysts for
· No gas cylinders or other external hydrogen source
use with the H-Cube®. Exposure to the
· No catalyst filtration or direct catalyst handling
catalyst is limited by removing the need
· Easy catalyst exchange
for filtration. The cartridges are easy to install and dispose of, and significantly increase the ratio of the catalyst to the
efficient
hydrogen and substrate, which in turn
· Analyze reaction results after 2 minutes
increases the reaction rate.
· Perform up to 50 different validation conditions in a day· Higher reaction rates with increased phase mixing· Easy to use, touch screen controlled
5. Product collectorThe reaction mixture or product col-lects in the collection vial. The short reaction time (in most cases a few
Convenient
minutes) means that analytical sam-
· Compact size can be used in a standard laboratory fume
ples can be taken to measure product
hood
conversion and any necessary system
· No special training or skills required to operate
adjustments (temperatue, pressure,
· Can be coupled to standard liquid-handling robots for the
flow-rate, or catalyst) made immediately
integration of hydrogenation into an automated synthesis
to optimize the reaction.
process
ProduCT uPdaTe
The H-Cube® is now also available with stainless-steel reaction line. The new steel reaction line allows the H-Cube® to be used with a wider range of solvents which the standard PEEK reaction lines don´t tolerate.
www.thalesnano.com
The following CatCarts® are currently available:
· 10% Pd/C · Inert CatCart®: Quartz · Inert CatCart®: Titanium · (2,5% Pt 2,5% Pd)/C · Raney-Ni · 10% Pt/C · 5% Rh/C · 20% Pd (OH)2/C (Pearlmann's catalyst)
· Raney Cobalt · Raney Copper · 5% Pd/Al2O3
· 5% Pd/C · 5% Ru/Al2O3
· 5% Pt/Al2O3
· 5% Pd on CaCO3 / Pb (Lindlar's catalyst)
· 5% Ru/C · 5% Re/C · 5% Pt/C, Sulfided · 5% Rh/Al2O3
· PtO2 (Adam's Catalyst)
· Pricat NI 55/5P
ThalesNano's CatCarts®
· NP Pd(0)EnCatTM 30 * · 5% Pd/BaSO4
Thales´ CatCarts® contain sealed heterogeneous catalysts,
· Nickel sponge, promoted 1% Mo
which can be used in hydrogenation and other heterogeneously
· (5% Pd, 1% Fe)/C · (4,5% Ru, 0,5% Pd)/C
catalyzed reactions in the H-Cube®. Exposure to the catalyst is
· 1% Pd/Al
limited by removing the need for filtration, while the cartridges are
2O3
· 10% Pd/Al
easy to install and replace. In the CatCarts®, the ratio of catalyst
2O3
· Pd/C- Ethylenediamine
to hydrogen and substrate is significantly increased, which
· 1% Ir/C
results in faster reaction rates.
· Ni/Si-Al · 5% Pd/SiO2
CatCarts® come in three standard sizes (30, 55, 70 mm). The
· 1% Pd/C
smallest CatCarts® are used typically to reduce up to 1g of sub-
· 2% Pd/SrCO3
strate, while the longest CatCarts® can reduce up to 100 g of
· 1% Pt/Al2O3
material in a day with no signs of catalyst deactiviation.
· PdO · Pd black · [{RuCl2(mtppms)2}2]
· Wilkinson's Catalyst Rh(I)(TPP)3Cl polymer bound
· PdEnCatTM 30 * · PdEnCatTM TPP30 *, ** · Pd(II)EnCatTM BINAP 30 *, ** · Tetrakis (TPP)-palladium polymer bound· Pd(II)EnCatTM TOTP 30 *· RuO2
· IrO2
· Fibrecat 1001 · Fibrecat 1007 · Fibrecat 2003 · Fibrecat 2006 · 1% Pt/C · 5% Ir/CaCO3 · 5% Pt/C
If you require further information on the instrument, or would like to
The list of available CatCarts® is being constantly updated with new
have a Demonstration scheduled, please contact:
catalysts. In addition, Thales Nanotechnology wil make CatCarts® to order.
ThalesNano Inc.
Thales LLC,
* Encat is a trademark of Reaxa Ltd.
Záhony u. 7.
Princeton, NJ, USA
** Pd Encat technology, international patents have been applied for,
H-1031 Budapest, Hungary
Tel: (1) 732 274 3388
including PCT/GB 02/03135.
Tel: (36 1) 880 8500Fax: (36 1) 880 8501
E-mail: info@thalesnano.com
www.thalesnano.com
Chargement...
; "HYDROGENATION HCUBE")
